Category Archives: Organocatalysis

Celebrating our last publication!

Asymmetric Organocatalytic Synthesis of Substituted Chiral 1,4-Dihydropyridine Derivatives. Fernando Auria-Luna, Eugenia Marqués-López, M. Concepción Gimeno, Roghayeh Heiran, Somayeh Mohammadi, and Raquel P. Herrera, J. Org. Chem. 2017, 82, 5516–5523. Abstract. The first cinchona-alkaloid-organocatalyzed enantioselective synthesis of chiral 1,4-dihydropyridine derivatives is described. Bis-cinchona catalyst 3b … Continue reading

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Organocatalytic methods collection to obtain chiral 1,4-DHPs, just accepted in Adv. Synth. Catal.

Organocatalytic enantioselective synthesis of 1,4-dihydropyridines, Auria-Luna, F.; Marqués-López, E.; Herrera, R. P.  Adv. Synth. Catal. 2017, DOI 10.1002/adsc.201700300 Abstract. This review aims to bring light upon a very interesting group of compounds, the 1,4-dihydropyridines (1,4-DHPs). These structures are well-known pharmacophores, used for many years … Continue reading

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Organocatalytic Hydrophosphonylation Reaction of Carbonyl Groups

Organocatalytic Hydrophosphonylation Reaction of Carbonyl Groups. Herrera, R. P. Chem. Rec. 2017, DOI: 10.1002/tcr.201600129. Abstract. This revision is covering the limited examples reported for a pivotal strategy in the formation of C−P bonds such as the asymmetric organocatalytic hydrophosphonylation of carbonyl groups … Continue reading

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Exploring new audiences and forums!

Juanvi, has recently attended to the 8th European Symposium on Computing π-Conjugated Compounds, celebrated in Malaga from Jan. 27th to 28th. There, he presented an oral communication about the most recent results of his doctoral thesis in the field of … Continue reading

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A synergistic couple of catalysts

A new article has just been accepted. Congratulations! Gold(I) mediated thiourea organocatalyst activation: A synergic effect for asymmetric catalysis. Anabel Izaga, Raquel P. Herrera, M. Concepción Gimeno, ChemCatChem, 2017, 10.1002/cctc.201601527. Abstract. Several group 11 metal complexes with chiral thiourea organocatalysts have … Continue reading

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Synergistic catalysis from synergistic collaboration between UK and SPAIN

This is the first article of a synergistic collaboration between Southampton and Zaragoza, as well as the catalysis involved on it. The work has been developed in Dr. Ramon Rios’s lab at the University of Southampton, in collaboration with Prof. M. Concepción … Continue reading

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A day of mixing feelings…

A bit sad because it is the last day of Javi in the lab (but maybe he’ll come back soon!)…   … and very happy because Isaac found a 70% ee in his reaction! Congratulations!

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A further step towards understanding one of our best “friends”: aminoindanol-based thiourea

Hydrogen bonding networks in chiral thiourea organocatalysts. Evidence on the importance of the aminoindanol moiety. Gimeno, M. C.; Herrera, R. P. Cryst. Growth Des., 2016, 16, 5091–5099. Abstract. The crystal structures of four chiral thioureas, which are normally used as organocatalysts, are reported by … Continue reading

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Raquel publishes a review on organocatalytic transfer hydrogenation methodologies

In this review paper, Raquel compiles and describes pioneering and most recent examples of how new stereogenic center can be created, using organocatalytic transfer hydrogenation methodologies. Organocatalytic Transfer Hydrogenation and Hydrosilylation Reactions. Herrera, R. P. Top. Curr. Chem. 2016, 374, 29. DOI: 10.1007/s41061-016-0032-4. … Continue reading

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Enhancing the activity of a squaramide as organocatalyst through the novel concept of trifunctionality

It is well known the lower activity of organocatalysts as compared to most metal catalysts. As a result, developing new and more potent organocatalysts focuses a great deal of interest both for science and chemical industry. Herein, we present our … Continue reading

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