HOCA in the media

El Periódico de Aragón:


Aragón Radio:


Posted in Media, Raquel P. Herrera | Tagged , , , , , | Leave a comment

The young chemists and physicists of Aragon told us yesterday their work in the Faculty of Sciences

The 8th Young Aragonese Researchers Meeting took place yesterday (November 22th) in the Faculty of Sciences (Zaragoza).

8ª Jornada de Jóvenes Investigadores (Química y Física) de Aragón. (8ª JJIQFA)

Isaac, Anabel and Fernando successfully presented part of their Doctoral Thesis work. Congratulations!

Isaac in front of his poster about synthesis of warfarin.


Anabel presented her work about synthesis of metal-thioureas.


Fernando presented his work on dihydropyridines synthesis.

Posted in Conference, Congress, Dihydropyridines, Meeting, Metal-thiourea, Synthesis, Warfarin | Tagged , , , , , , , , , , , , , , , , | Leave a comment

One more year, Chemistry and Young people have had an appointment; this time in the beautiful city of Toledo

Our guys attended last week (5-8 NOVEMBER 2018) the last Young Research Symposium of the Spanish Chemistry Society, celebrated in Toledo.


They presented their work and enjoyed Toledo!!!

Posted in Congress, Having fun, Meeting | Tagged , , , , , , , , , , , , | Leave a comment

Meeting of the Leonardo Network of the BBVA Foundation

Meeting of the Leonardo Network of the BBVA Foundation

Yesterday, Raquel attended to this big event celebrated in Madrid. Congratulations once again!

Posted in Award, Raquel P. Herrera | Tagged , , , , | Leave a comment

Celebrating the publication of a new article!

First Organocatalytic Asymmetric Synthesis of 1-Benzamido-1,4-Dihydropyridine Derivatives,  Auria-Luna, F.; Marqués-López, E.; Herrera, R. P.  Molecules 2018, 23(10), 2692. https://doi.org/10.3390/molecules23102692. Special Issue “Stereogenic Centers

Abstract. Preliminary results concerning the first asymmetric synthesis of highly functionalized 1-benzamido-1,4-dihydropyridine derivatives via the reaction of hydrazones with alkylidenemalononitriles in the presence of β-isocupreidine catalyst are reported. The moderate, but promising, enantioselectivity observed (40–54% ee), opens the door to a new area of research for the asymmetric construction of new chiral 1,4-dihydropyridine derivatives, whose enantioselective catalytic preparation are still very limited. Moreover, the use of hydrazones for the enantioselective construction of chiral 1,4-dihydropyridines has been overlooked in the literature so far. Therefore, our research represents a pivotal example in this field which remains still unexplored.

Keywordschiral base; 1,4-dihydropyridine; enantioselective; hydrazone; organocatalysis

Congratulations Fer!!

Posted in Dihydropyridines, Eugenia Marqués-López, Heterocycle, Organic chemistry, Organocatalysis, Publication, Raquel P. Herrera, Research | Tagged , , , , , , , , , , | Leave a comment

Raquel is in the Basque Country

She attendes to the 7ª JORNADAS DE LA RED DE CATÁLISIS ASIMÉTRICA (7J_CASI) – 2018 (4-5th October. Hondarribia – Fuenterrabía, Gipuzkoa, Spain).

No doubt about she will also enjoy the great Basque food!

Posted in Conference, Congress, Raquel P. Herrera | Tagged , , , , , , , , , , | Leave a comment

Raquel combined holidays and work last summer

Gold 2018 (15-18 July, 2018 – Paris, France)

Gold(I)-Mediated Thiourea Organocatalyst Activation: A Synergic Effect for Asymmetric Catalysis. Raquel P. Herrera, Anabel Izaga, Juan V. Alegre-Requena, M. Concepción Gimeno. (S5 O5)


Groupe d’Etudes en Chimie Organique 59 (26-31 August, 2018 – Cabourg, France)

New Trends in Hydrogen Bonds based Catalysts. Raquel P. Herrera.


She met in Cabourg an old friend, Christophe Pichon.

Posted in Uncategorized | Leave a comment

Some HOCA members attend to GEQO in Zaragoza

These days (5th to 7th September 2018)  XXXVI CONGRESS OF THE ORGANOMETALLIC CHEMISTRY GROUP (GEQO) is taking place in Zaragoza.

HOCA is involved in its organization since Raquel is member of the Organaizing Committee. Is going to be a great success!!  Congratullations 😉

We present very nice and recent results from Fernando’s thesis project: Trapping enolates in pure water for the synthesis of 4H-pyran derivatives and study of their biological activity. Fernando Auria-Luna, Eugenia Marqués-López, and Raquel P. Herrera.




Posted in Congress, Eugenia Marqués-López, Heterocycle, Multicomponent reaction, Raquel P. Herrera, Research, Synthesis | Tagged , , , , , , | Leave a comment

Gold Catalyzed Multicomponent Reactions beyond A3Coupling

Gold Catalyzed Multicomponent Reactions beyond A3Coupling

Renso Visbal, Sara Graus, Raquel P. Herrera, M. Concepción Gimeno

Molecules 201823(9), 2255. https://doi.org/10.3390/molecules23092255

Abstract: The preparation of complex architectures has inspired the search for new methods and new processes in organic synthesis. Multicomponent reactions have become an interesting approach to achieve such molecular diversity and complexity. This review intends to illustrate important gold-catalyzed examples for the past ten years leading to interesting skeletons involved in biologically active compounds.

Keywords: β-alkoxyketones; butenolides; catalysis; ethers; gold; 3,4-dihydropyrimidin-2(1H)-ones; 1,4-dihydropyridines; multicomponent reactions; oxazoles; pyridines; spirocycles; thiazolo-quinolines

Posted in Collaboration, Gold, Publication, Raquel P. Herrera, Review | Tagged , , , , , , , , , , , , , , , , , , , , , | Leave a comment

Efficient Gold(I) Acyclic Diaminocarbenes for the Synthesis of Propargylamines and Indolizines

Efficient Gold(I) Acyclic Diaminocarbenes for the Synthesis of Propargylamines and Indolizines

Mélanie Aliaga-Lavrijsen, Raquel P. Herrera, M. Dolores Villacampa, and M. Concepción Gimeno

ACS Omega20183, 9805–9813.

Abstract: Mononuclear gold(I) acyclic diaminocarbenes (ADCs) were prepared by the reaction of 1,2-cyclohexanediamine with the corresponding isocyanide complexes [AuCl(CNR)] (R = Cy, tBu). The three-component coupling of aldehydes, amines, and alkynes was investigated by using these gold(I) ADC complexes. The new gold(I) metal complexes are highly efficient catalysts for the synthesis of propargylamines and indolizines in the absence of solvent and in mild conditions. This method affords the corresponding final products with excellent yields in short reaction times. Additionally, chiral gold(I) complexes with ADCs have been prepared and tried in the enantioselective synthesis of propargylamines.

Topics: Carbene complexes; Catalysts; Multicomponent reaction; Organic compounds and Functional groups; Physical and chemical processes

Posted in Collaboration, Gold, Multicomponent reaction, Publication, Raquel P. Herrera | Tagged , , , , , , , , , , , | Leave a comment