Miryam Garcés Marín. “Searching for more sustainable and effective methods for the synthesis of chiral chromenes of biological importance” Supervisors: Dr. Eugenia Marqués-López and Dr. Raquel P. Herrera.
Juan Carlos Pérez Sánchez. “Synthesis and study of new metal-organocatalysts for dual catalysis” Supervisors: Dr. Raquel P. Herrera and Prof. M. Concepción Gimeno.
Sandra Ardevines Asín. “Organocatalytic reactions for the synthesis of intermediates of biological interest” Supervisors: Dr. Eugenia Marqués-López and Dr. Raquel P. Herrera.
Christian Ascaso Alegre. “Chemoenzymatic cascades for the generation of new C-C bonds” Supervisors: Dr. Juan Mangas-Sánchez and Dr. Raquel P. Herrera.
Guillermo Canudo Barreras. “Synthesis of heterocycles through gold catalysis” Supervisors: Dr. Raquel P. Herrera and Prof. M. Concepción Gimeno.
Alberto Eizaguerri Serrano. “Application of organo- and bio- catalytic strategies for the preparation of products of industrial interest” Supervisors: Dr. Juan Mangas-Sánchez and Dr. Raquel P. Herrera.
Inés Sebastián Molia. “Synthesis of gold(I) and gold(III) models of metalloenzymes: Catalytic and therapeutic properties” Supervisors: Dr. Juan Mangas Sánchez and Prof. M. Concepción Gimeno.
Abstract. Two new organic–inorganic salts of perhalidometallates with protonated organic amine cations have been synthesized and characterized by X-ray diffraction and thermal analysis. (CHBMAH2)ZnBr4·3/2H2O 1 and (CHBMAH2)ZnCl44 [(CHBMAH2)2+: 1,3-cyclohexanebis(methylammonium)] were obtained in single-crystal form. The crystal packing in all of the obtained compounds is governed by the formation of various non-covalent intermolecular forces between tetrahalidometallate anions and organic cations, assisted by water molecules in the hydrates. Hirshfeld surface analysis denotes that the most important contributions to the crystal packing are X···H/H···X (X: Cl, Br, I) and H···H interactions. Interestingly, the compound 1,3-cyclohexanebis(methylammonium)tetrachloridozincate (II) dihydrate, (CHBMAH2)ZnCl4·2H2O 2, undergoes thermally-triggered single-crystal-to-single-crystal (SCSC) transformation upon dehydration to produce a supramolecular solid compound, 1,3-cyclohexanebis(methylammonium) tetrachloridozincate (II), (CHBMAH2)ZnCl44. The SCSC transformation causes changes in the lattice parameters and a structural rearrangement. Furthermore, the catalytic properties of (CHBMAH2)ZnCl4·2H2O 2 and (CHBMAH2)CdI4·2H2O 3 have been explored in the acetalization process using various uncommon alcohols, beyond methanol or ethanol, for the first time in the literature, with outstanding results, and opening the door to the formation of alternative acetals.
Unconventional Gold-Catalyzed One-Pot/Multicomponent Synthesis of Propargylamines Starting from Benzyl Alcohols, Zárate-Roldán, S.; Gimeno, M. C.; Herrera, R. P. Catalysts2021, 11, 513. https://doi.org/10.3390/catal11040513.
Abstract. A formal homogeneous gold-catalyzed A3-coupling, starting from benzyl alcohols, is reported for the straightforward synthesis of propargylamines. This is the first process where these highly valuable compounds have been synthesized, starting from the corresponding alcohols in a one-pot oxidation procedure using MnO2, followed by a HAuCl4·3H2O catalyzed multicomponent reaction. The final products are obtained with very good yields in short reaction times, which is of fundamental interest for the synthesis of pharmaceuticals. The usefulness and efficiency of our methodology is successfully compared against the same reaction starting from aldehydes.
Abstract. In this contribution, we provide an overview of the main avenues that have emerged in gold coordination chemistry during the last years. The unique properties of gold have motivated research in gold chemistry, and especially regarding the properties and applications of gold compounds in catalysis, medicine, and materials chemistry. The advances in the synthesis and knowledge of gold coordination compounds have been possible with the design of novel ligands becoming relevant motifs that have allowed the preparation of elusive complexes in this area of research. Strong donor ligands with easily modulable electronic and steric properties, such as stable singlet carbenes or cyclometalated ligands, have been decisive in the stabilization of gold(0) species, gold fluoride complexes, gold hydrides, unprecedented π complexes, or cluster derivatives. These new ligands have been important not only from the fundamental structure and bonding studies but also for the synthesis of sophisticated catalysts to improve activity and selectivity of organic transformations. Moreover, they have enabled the facile oxidative addition from gold(I) to gold(III) and the design of a plethora of complexes with specific properties.