First aromatic amine organocatalysed activation of α,β-unsaturated ketones, Sonsona, I. G.; Marqués-López, E.; Gimeno, M. C.; Herrera, R. P. New J. Chem. 2019, 43, 12233-12240. DOI: 10.1039/c9nj02392e.
Abstract. This work provides an unprecedented example of a chiral aromatic amine used to activate α,β-unsaturated ketones in asymmetric aminocatalysis. Chiral aromatic diamine VII has been efficiently employed, as a proof of concept, in the Michael addition reaction between benzylideneacetones (1a–f) and coumarins (2a–d). The reaction gives rise to warfarin derivatives 3 with promising results using this family of catalysts for the first time. The additional studies performed supported the bifunctional mode of activation of the chiral catalyst VII and the covalent nature of the interactions between the catalyst VII and benzylideneacetones 1.
Posted in Publication, Warfarin
Tagged 2019, Aromatic amine, Asymmetric organocatalysis, Eugenia Marqués-López, Isaac G. Sonsona, New J. Chem., Organocatalysis, Prof. Gimeno, Publication, Raquel P. Herrera, Warfarin
… all together around the table, enjoying nice food and nice company!
Fer, Isaac, Guillermo, Sara, Raquel, Pablo, Gonzalo, Javier, Maru.
Posted in Fun, Goodbye, Season's Greetings
Tagged 2019, Eugenia Marqués-López, Fernando Auria-Luna, Gonzalo Murillo, Group party, Guillermo Canudo, Isaac G. Sonsona, Japanese restaurant, Javier Mindón, Pablo Murillo, Raquel P. Herrera, Sara Gil
Raquel joined the XI REUNIÓN CIENTÍFICA DE BIOINORGÁNICA, celebrated in Lugo (Spain) from 30 June to 3 July 2019. She presented her work “Synthesis of metal complexes of group 11 with thiourea or squaramides ligands: Study of their biological properties” (Anabel Izaga, Daniel Salvador-Gil, M. Lourdes Ortego, Raquel P. Herrera y M. Concepción Gimeno), which has been awarded as the best poster. Congratulations!
Marta, Vanesa, Conchita and Raquel. Gala dinner.
Raquel receiving the award to the best poster.
Last monday, may 27th, Fer presented very successfully, the most recent results of his PhD projects in the II Jornada Doctoral, celebrated in the Faculty of Sciences of our University.
Posted in Conference, Dihydropyridines, Doctorate, PhD thesis, Research
Tagged 2019, Conference, Dihydropyridines, Doctoral School, Faculty of Science, Fernando Auria-Luna, II Jornada Doctoral, Organic Chemistry Doctoral Program, Organocatalysis, University of Zaragoza
… and we celebrate it meeting in one of our favorite places!
After enjoying Japanese food…
Last March 15th, Isaac had the Defense of his Doctoral Thesis and he did it excellent!
CUM LAUDE 😉
We wish all the best Dr. Sonsona. Thank you very much!
Raquel gave an spectacular conference about Chemistry through the mirror in the evolution of drugs, within Conferences Program (CSIC): “What do we know about…?”
Last Tuesday, March 12, Conchita Gimeno collected her award “March 8, Women of the Campo de Cariñena 2019”. After that, she and Raquel gave very nice talks to celebrate Women’s day. Congratulations!
Last Friday, March 8th, Dr. Luca Bernardi (University of Bologna) visited Zaragoza and gave us a wonderful talk as a present, about “Asymmetric Organocatalysis: Principles and Applications“. Thanks a lot, Luca!