El Periódico de Aragón:
Aragón Radio:
The 8th Young Aragonese Researchers Meeting took place yesterday (November 22th) in the Faculty of Sciences (Zaragoza).
8ª Jornada de Jóvenes Investigadores (Química y Física) de Aragón. (8ª JJIQFA)
Isaac, Anabel and Fernando successfully presented part of their Doctoral Thesis work. Congratulations!
Isaac in front of his poster about synthesis of warfarin.
Anabel presented her work about synthesis of metal-thioureas.
Fernando presented his work on dihydropyridines synthesis.
Our guys attended last week (5-8 NOVEMBER 2018) the last Young Research Symposium of the Spanish Chemistry Society, celebrated in Toledo.
They presented their work and enjoyed Toledo!!!
Meeting of the Leonardo Network of the BBVA Foundation
Yesterday, Raquel attended to this big event celebrated in Madrid. Congratulations once again!
First Organocatalytic Asymmetric Synthesis of 1-Benzamido-1,4-Dihydropyridine Derivatives, Auria-Luna, F.; Marqués-López, E.; Herrera, R. P. Molecules 2018, 23(10), 2692. https://doi.org/10.3390/molecules23102692. Special Issue “Stereogenic Centers“
Abstract. Preliminary results concerning the first asymmetric synthesis of highly functionalized 1-benzamido-1,4-dihydropyridine derivatives via the reaction of hydrazones with alkylidenemalononitriles in the presence of β-isocupreidine catalyst are reported. The moderate, but promising, enantioselectivity observed (40–54% ee), opens the door to a new area of research for the asymmetric construction of new chiral 1,4-dihydropyridine derivatives, whose enantioselective catalytic preparation are still very limited. Moreover, the use of hydrazones for the enantioselective construction of chiral 1,4-dihydropyridines has been overlooked in the literature so far. Therefore, our research represents a pivotal example in this field which remains still unexplored.
Keywords: chiral base; 1,4-dihydropyridine; enantioselective; hydrazone; organocatalysis
Congratulations Fer!!
She attendes to the 7ª JORNADAS DE LA RED DE CATÁLISIS ASIMÉTRICA (7J_CASI) – 2018 (4-5th October. Hondarribia – Fuenterrabía, Gipuzkoa, Spain).
No doubt about she will also enjoy the great Basque food!
Gold 2018 (15-18 July, 2018 – Paris, France)
Gold(I)-Mediated Thiourea Organocatalyst Activation: A Synergic Effect for Asymmetric Catalysis. Raquel P. Herrera, Anabel Izaga, Juan V. Alegre-Requena, M. Concepción Gimeno. (S5 O5)
Groupe d’Etudes en Chimie Organique 59 (26-31 August, 2018 – Cabourg, France)
New Trends in Hydrogen Bonds based Catalysts. Raquel P. Herrera.
She met in Cabourg an old friend, Christophe Pichon.
These days (5th to 7th September 2018) XXXVI CONGRESS OF THE ORGANOMETALLIC CHEMISTRY GROUP (GEQO) is taking place in Zaragoza.
HOCA is involved in its organization since Raquel is member of the Organaizing Committee. Is going to be a great success!! Congratullations 😉
We present very nice and recent results from Fernando’s thesis project: Trapping enolates in pure water for the synthesis of 4H-pyran derivatives and study of their biological activity. Fernando Auria-Luna, Eugenia Marqués-López, and Raquel P. Herrera.
Gold Catalyzed Multicomponent Reactions beyond A3Coupling
Renso Visbal, Sara Graus, Raquel P. Herrera, M. Concepción Gimeno
Molecules 2018, 23(9), 2255. https://doi.org/10.3390/molecules23092255
Abstract: The preparation of complex architectures has inspired the search for new methods and new processes in organic synthesis. Multicomponent reactions have become an interesting approach to achieve such molecular diversity and complexity. This review intends to illustrate important gold-catalyzed examples for the past ten years leading to interesting skeletons involved in biologically active compounds.
Keywords: β-alkoxyketones; butenolides; catalysis; ethers; gold; 3,4-dihydropyrimidin-2(1H)-ones; 1,4-dihydropyridines; multicomponent reactions; oxazoles; pyridines; spirocycles; thiazolo-quinolines
Efficient Gold(I) Acyclic Diaminocarbenes for the Synthesis of Propargylamines and Indolizines
Mélanie Aliaga-Lavrijsen, Raquel P. Herrera, M. Dolores Villacampa, and M. Concepción Gimeno
ACS Omega, 2018, 3, 9805–9813.
Abstract: Mononuclear gold(I) acyclic diaminocarbenes (ADCs) were prepared by the reaction of 1,2-cyclohexanediamine with the corresponding isocyanide complexes [AuCl(CNR)] (R = Cy, tBu). The three-component coupling of aldehydes, amines, and alkynes was investigated by using these gold(I) ADC complexes. The new gold(I) metal complexes are highly efficient catalysts for the synthesis of propargylamines and indolizines in the absence of solvent and in mild conditions. This method affords the corresponding final products with excellent yields in short reaction times. Additionally, chiral gold(I) complexes with ADCs have been prepared and tried in the enantioselective synthesis of propargylamines.
Topics: Carbene complexes; Catalysts; Multicomponent reaction; Organic compounds and Functional groups; Physical and chemical processes
