Herrera-OrganoCatalisis Asimétrica Group

A compilation of methods for an easy substitution of alcohols in water, just published

Posted on April 2, 2017 by mmaamarq

Direct Substitution of Alcohols in Pure Water by Brønsted Acid Catalysis. Ortiz, R.; Herrera, R. P. Molecules 2017, 22(4), 574; DOI:10.3390/molecules22040574.

This article belongs to the Special Issue Women in Organic Chemistry.

Abstract. With the increasing concern for sustainability, the use of environmentally friendly media to perform chemical processes has attracted the attention of many research groups. Among them, the use of water, as the unique solvent for reactions, is currently an active area of research. One process of particular interest is the direct nucleophilic substitution of an alcohol avoiding its preliminary transformation into a good leaving group, since one of the by-products in this approach would be water. The direct substitution of allylic, benzylic, and tertiary alcohols has been achieved through S_N1-type reactions with catalytic amounts of Brønsted or Lewis acids; however, organic solvents are often required. In this review, the pioneering S_N1 approaches performed in pure water and in the absence of a metal based Lewis acid are compiled and discussed.

Keywords: alcohol; non-catalyzed; organocatalysis; S_N1; water

Posted in Publication, Raquel P. Herrera, Review | Tagged 2017, Alcohol, Non-catalyzed, Organocatalysis, Publication, Raquel P. Herrera, Review, Rosa Ortiz, SN1, Special Issue Women in Organic Chemistry, Water | Leave a comment

V Jornadas Doctorales G-9 (Palma de Mallorca)

Posted on February 12, 2017 by mmaamarq

Juanvi was selected by the University of Zaragoza to participate in the V Jornadas Doctorales G-9 (Palma de Mallorca, del 8 al 10 de febrero de 2017). He presented there, his doctorate topic: SQUARAMIDES.

Juanvi giving his talk about SQUARAMIDES in the “V Jornadas Doctorales G-9”.

Posted in Conference, Doctorate, Meeting, Squaramide | Tagged 2017, Asymmetric organocatalysis, Conference, Juan V. Alegre-Requena, Palma de Mallorca, Poster, Squaramide, Symposium, University of Zaragoza, V Jornadas Doctorales G-9 | Leave a comment

Organocatalytic Hydrophosphonylation Reaction of Carbonyl Groups

Posted on February 12, 2017 by mmaamarq

Organocatalytic Hydrophosphonylation Reaction of Carbonyl Groups. Herrera, R. P. Chem. Rec. 2017, DOI: 10.1002/tcr.201600129.

Abstract. This revision is covering the limited examples reported for a pivotal strategy in the formation of C−P bonds such as the asymmetric organocatalytic hydrophosphonylation of carbonyl groups (Pudovik reaction). The scope and limitations, and the proposed mechanisms for the scarce different possibilities of asymmetric induction are also shown. The recent evolution and future trends of this undeveloped approach are commented.

Keywords. asymmetry; hydrophosphonylation; α-hydroxy phosphonates; organocatalysis; phosphite; Pudovik

Posted in Organocatalysis, Publication, Raquel P. Herrera, Review | Tagged 2017, Asymmetry, Hydrophosphonylation, α-Hydroxy phosphonates, Organocatalysis, Phosphite, Pudovik, Raquel P. Herrera | Leave a comment

Exploring new audiences and forums!

Posted on February 1, 2017 by mmaamarq

Juanvi, has recently attended to the 8th European Symposium on Computing π-Conjugated Compounds, celebrated in Malaga from Jan. 27th to 28th.

There, he presented an oral communication about the most recent results of his doctoral thesis in the field of computational studies of organocatalytic reactions, entitled “Studying Computationally Anion-π Interactions for the First Time in Asymmetric Catalysis: Squaramide-Catalyzed Henry Reaction”

For sure, he learnt a lot and enjoyed this wonderful city.
Well done!

Posted in Computational chemistry, Conference, Congress, Meeting, Organocatalysis, Research, Squaramide | Tagged 2017, 8th European Symposium on Computing π-Conjugated Compounds, Asymmetric organocatalysis, Computational chemistry, Henry reaction, Juan V. Alegre-Requena, Malaga, Oral communication, Organocatalysis, Squaramide | Leave a comment

New responsibilities…

Posted on January 26, 2017 by mmaamarq

Maru is now the Assistant Director for International Affairs at the Technological College of Huesca, taking part of the new direction team.

Congratulations!

Posted in EPS (UZ), Eugenia Marqués-López | Tagged 2017, Assistant Director for International Affairs, EPS, Escuela Politécnica Superior de Huesca, Eugenia Marqués-López, Technological College of Huesca, University of Zaragoza | Leave a comment

A synergistic couple of catalysts

Posted on January 20, 2017 by mmaamarq

A new article has just been accepted. Congratulations!

Gold(I) mediated thiourea organocatalyst activation: A synergic effect for asymmetric catalysis. Anabel Izaga, Raquel P. Herrera, M. Concepción Gimeno, ChemCatChem, 2017, 10.1002/cctc.201601527.

Abstract. Several group 11 metal complexes with chiral thiourea organocatalysts have been prepared and tested as organocatalysts. The promising results on the influence of metal assisted thiourea organocatalysts in the asymmetric Friedel-Crafts alkylation of indole with nitrostyrene are described. Better results with the metal complexes have been achieved because of the cooperative effects between the chiral thiourea and the metal. The synergic effect between both species is higher than the effect promoted by each one separately, especially for gold(I). These outcomes are attributed to a pioneering gold(I) activation of the thiourea catalysts, affording a more acidic and rigid catalytic complex than that provided by the thiourea alone. Furthermore, the use of the gold-thiourea organocatalyst allows reducing the catalyst loading to 1-3 mol%. This contribution could become an important starting point for further investigations opening a new line of research overlooked so far in the literature.

graphical_abstract

Keywords. thiourea, gold, asymmetric, organocatalysis, synergy

Posted in Catalysis, Collaboration, Gold, Organocatalysis, Raquel P. Herrera, Research, Thiourea | Tagged 2017, Asymmetric organocatalysis, ChemCatChem, Collaboration, Friedel-Crafts, Gold, Organocatalysis, Prof. Gimeno, Synergistic catalysis, Synergy, Thiourea | Leave a comment

Raquel is now a member of the Editorial Board of Molecules

Posted on January 20, 2017 by mmaamarq

Section Board for ‘Organic Synthesis’

Dr. Raquel P. Herrera

Laboratorio de Organocatálisis Asimétrica, Instituto de Síntesis Química y Catálisis Homogénea (CSIC-UZ), Departamento de Química Orgánica, Facultad de Ciencias Plz. de San Francisco s/n, Universidad de Zaragoza, E-50009 Zaragoza, Spain
Website | E-Mail
Interests: thiourea; indole; organocatalysts; hydrogen bond; Michael addition
Special Issues and Collections in MDPI journals:
Topical Collection: Recent Advances in Organocatalysis