Roberto will be with us this summer working in the lab before leaving for an Erasmus academic stay in September.
Raquel is now in São Paulo (Brazil), attending to the IUPAC 2017 – 46th World Chemistry Congress. There, our collaborator, Concepción Gimeno, received her award “IUPAC 2017 Distinguished Women in Chemistry or Chemical Engineering”.
It seems they are enjoying! 😉
Fernando is now in Sitges attending to the “XXXVI Reunión Bienal de la Real Social Española de Química“. He has presented his talk about “Organocatalytic Synthesis of Chiral 1,4-Dihydropiridines”. Congratulations!
Enjoy Fer…
Raquel joins these days the 14th International Symposium on Applied Bioinorganic Chemistry and presents her work together with Prof. Gimeno: “First synthesis of group 11 metal complexes with α-hydrazidophosphonate ligands and biological study” (Raquel P. Herrera, Daniel Salvador, Lourdes Ortego, M. Concepción Gimeno).
Conchita and Raquel in front of their poster.
Asymmetric Organocatalytic Synthesis of Substituted Chiral 1,4-Dihydropyridine Derivatives. Fernando Auria-Luna, Eugenia Marqués-López, M. Concepción Gimeno, Roghayeh Heiran, Somayeh Mohammadi, and Raquel P. Herrera, J. Org. Chem. 2017, 82, 5516–5523.
Abstract. The first cinchona-alkaloid-organocatalyzed enantioselective synthesis of chiral 1,4-dihydropyridine derivatives is described. Bis-cinchona catalyst 3b activates the Michael addition reaction between malononitrile derivatives 2 and enamines 1, affording the appealing and highly substituted 1,4-dihydropyridines 4 with very good results in most cases. This is one of very few examples of the synthesis of chiral 1,4-dihydropyridines by an enantioselective catalytic procedure. The highly substituted final compounds are of interest for their potential biological activity. This efficient protocol opens the door to a new area of research for the asymmetric construction of these skeletons for which enantioselective syntheses are still very limited.
Fernando, Juanvi, Maru, Javi, Isaac, Sandra and Raquel (left to rigth).
Congratulations Fer!
Our collaborator, Concepción Gimeno, awardee of the “IUPAC 2017 Distinguished Women in Chemistry or Chemical Engineering”
Congratulations!
Conchita
Last week, we celebrated Isaac’s birthday with a delicious cake that Sandra cooked for us.
Thank you!
Last friday Raquel and Javi enjoyed a football match in “La Romareda” supporting to Real Zaragoza (vs Cadiz CF).
Real Zaragoza scored first a goal, but finally the result was very frustrating (1-1). Next time!
Organocatalytic enantioselective synthesis of 1,4-dihydropyridines, Auria-Luna, F.; Marqués-López, E.; Herrera, R. P. Adv. Synth. Catal. 2017, DOI 10.1002/adsc.201700300
Abstract. This review aims to bring light upon a very interesting group of compounds, the 1,4-dihydropyridines (1,4-DHPs). These structures are well-known pharmacophores, used for many years to treat cardiovascular diseases because of their activity as calcium channel blockers. In addition, their potential as drugs to treat other affections has been recently exposed. The racemic synthesis of 1,4-DHPs has been well studied, while the asymmetric approaches are mainly based on the use of chiral auxiliaries or chiral resolutions. However, there are scarce examples regarding enantioselective organocatalytic methods. Herein, we will summarize the existing examples in this field of research.
Keywords. 1,4-dihydropyridine; 1,4–DHP; organocatalysis; (thio)urea; BINOL-derived phosphoric acid; aminocatalysis
Congratulations Fer!!
Few weeks ago, we celebrated Raquel’s birthday. It was a nice party for a special number-40 😉
Enjoy it!
Herrera-OrganoCatalisis Asimétrica Group 