Bioactive and luminescent indole and isatin based gold(I) derivatives, Fernández-Moreira, V.; Val-Campillo, C.; Ospino, I.; Herrera, R. P.; Marzo, I.; Laguna, A.; Gimeno, M. C. Dalton Trans. 2019. DOI: 10.1039/C8DT00298C
Last January 24th, we enjoyed a very interesting seminar about Introduction to Drug Development within the ISQCH Conferences Cycle. The seminar was taught by Jorge Esquivias Provencio (Project leader, Tuberculosis unit) and María Santos Martínez (DMPK Head), both at the Tres Cantos GSK. They were invited by Raquel P. Herrera and Conchita Gimeno, who have established a promising collaboration with the company.
We learnt a lot! Thanks!
Raquel introducing the speakers.
Conchita, Jorge, Raquel and María (from left to right).
Anticancer Properties of Gold Complexes with Biologically Relevant Ligands, Fernández-Moreira, V.; Herrera, R. P.; Gimeno, M. C. Pure Appl. Chem. 2018, DOI: https://doi.org/10.1515/pac-2018-0901
Abstract. The present review highlights our findings in the field of antitumor gold complexes bearing biologically relevant molecules, such as DNA-bases, amino acids or peptide derivatives. The results show that very active complexes are achieved with this sort of ligands in several cancer cells. In these compounds the gold center is bonded to these biological molecules mainly through a sulfur atom belonging to a cysteine moiety or to a thionicotinic moiety as result of the functionalization of the biological compounds, and additionally phosphines or N-heterocyclic carbenes are present as ancillary ligands. These robust compounds are stable in the biological media and can be transported to their targets without previous deactivation. The presence of these scaffolds represents a good approach to obtain complexes with improved biologically activity, better transport and biodistribution to cancer cells. Thioredoxin reductase (TrxR) has been shown as the main target for these complexes and in some cases, DNA interactions has been also observed.
Keywords. amino acids; antitumor compounds; Distinguished Women in Chemistry and Chemical Engineering; DNA-base derivatives; gold complexes; peptides
El Periódico de Aragón:
Aragón Radio:
The 8th Young Aragonese Researchers Meeting took place yesterday (November 22th) in the Faculty of Sciences (Zaragoza).
8ª Jornada de Jóvenes Investigadores (Química y Física) de Aragón. (8ª JJIQFA)
Isaac, Anabel and Fernando successfully presented part of their Doctoral Thesis work. Congratulations!
Isaac in front of his poster about synthesis of warfarin.
Anabel presented her work about synthesis of metal-thioureas.
Fernando presented his work on dihydropyridines synthesis.
Our guys attended last week (5-8 NOVEMBER 2018) the last Young Research Symposium of the Spanish Chemistry Society, celebrated in Toledo.
They presented their work and enjoyed Toledo!!!
Meeting of the Leonardo Network of the BBVA Foundation
Yesterday, Raquel attended to this big event celebrated in Madrid. Congratulations once again!
First Organocatalytic Asymmetric Synthesis of 1-Benzamido-1,4-Dihydropyridine Derivatives, Auria-Luna, F.; Marqués-López, E.; Herrera, R. P. Molecules 2018, 23(10), 2692. https://doi.org/10.3390/molecules23102692. Special Issue “Stereogenic Centers“
Abstract. Preliminary results concerning the first asymmetric synthesis of highly functionalized 1-benzamido-1,4-dihydropyridine derivatives via the reaction of hydrazones with alkylidenemalononitriles in the presence of β-isocupreidine catalyst are reported. The moderate, but promising, enantioselectivity observed (40–54% ee), opens the door to a new area of research for the asymmetric construction of new chiral 1,4-dihydropyridine derivatives, whose enantioselective catalytic preparation are still very limited. Moreover, the use of hydrazones for the enantioselective construction of chiral 1,4-dihydropyridines has been overlooked in the literature so far. Therefore, our research represents a pivotal example in this field which remains still unexplored.
Keywords: chiral base; 1,4-dihydropyridine; enantioselective; hydrazone; organocatalysis
Congratulations Fer!!
She attendes to the 7ª JORNADAS DE LA RED DE CATÁLISIS ASIMÉTRICA (7J_CASI) – 2018 (4-5th October. Hondarribia – Fuenterrabía, Gipuzkoa, Spain).
No doubt about she will also enjoy the great Basque food!
Gold 2018 (15-18 July, 2018 – Paris, France)
Gold(I)-Mediated Thiourea Organocatalyst Activation: A Synergic Effect for Asymmetric Catalysis. Raquel P. Herrera, Anabel Izaga, Juan V. Alegre-Requena, M. Concepción Gimeno. (S5 O5)
Groupe d’Etudes en Chimie Organique 59 (26-31 August, 2018 – Cabourg, France)
New Trends in Hydrogen Bonds based Catalysts. Raquel P. Herrera.
She met in Cabourg an old friend, Christophe Pichon.
Herrera-OrganoCatalisis Asimétrica Group 