This is a nice fruit of the intensive and intriguing collaboration between our research group and Prof. Gimeno’s group (ISQCH).
Congratulation guys!
“Synthesis of Luminescent Squaramide Monoesters: Cytotoxicity and Cell Imaging Studies in HeLa Cells” Fernandez-Moreira, V.; Alegre-Requena, J. V.; Herrera, R. P.; Marzo, I.; Gimeno, M. C. RSC Adv., 2016, Accepted Manuscript. DOI: 10.1039/C5RA24521D
Abstract. Novel luminescent 
squaramide monoesters functionalised with different fluorophore groups have been synthesised and explored in cell imaging for the first time. Cytotoxicity studies performed in HeLa cervical cancer cells revealed high activity for some of these novel structures, pointing out the importance of the fluorescent fragment in the efficiency of these promising anticancer agents. In addition, fluorescence cell microscopy disclosed the different biodistribution behaviour depending on the fluorescent moiety, and the possibility of nuclear localisation of chiral non planar squaramide monoesters.
