Our most recent review paper has just come out off the press. It has been published as open access in Beilstein J. Org. Chem. In this paper, by gathering relevant and illustrative examples, we show the ability of conferring bifunctionality to the catalyst of aminoindanol, one key scaffold in the field of organocatalysis. We invite you to browse through this newly published paper and learn about this amazing structure. We hope you enjoy it!
“The aminoindanol core as a key scaffold in bifunctional organocatalysts” doi:10.3762/bjoc.12.50 This article is part of the Thematic Series “Bifunctional catalysis”. Guest Editor: D. J. Dixon., I. G.; Beilstein J. Org. Chem. 2016, 12, 505–523;
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Abstract. The 1,2-aminoindanol scaffold has been found to be very efficient, enhancing the enantioselectivity when present in organocatalysts. This may be explained by its ability to induce a bifunctional activation of the substrates involved in the reaction. Thus, it is easy to find hydrogen-bonding organocatalysts ((thio)ureas, squaramides, quinolinium thioamide, etc.) in the literature containing this favored structural core. They have been successfully employed in reactions such as Friedel–Crafts alkylation, Michael addition, Diels–Alder and aza-Henry reactions. However, the 1,2-aminoindanol core incorporated into proline derivatives has been scarcely explored. Herein, the most representative and illustrative examples are compiled and this review will be mainly focused on the cases where the aminoindanol moiety confers bifunctionality to the organocatalysts.
Keywords. aminocatalysis; 1,2-aminoindanol; bifunctional; organocatalysis; hydrogen bonding