Available “Early View” of the last publication with David and Juanvi

Self‐Assembly of Hollow Organic Nanotubes Driven by Arene Regioisomerism, Alegre-Requena, J. V.; Herrera, R. P.; Díaz Díaz, D. ChemPlusChem 2020, https://doi.org/10.1002/cplu.202000473

Abstract. Arene regioisomerism in low‐molecular‐weight gelators can be exploited as a tool to modulate the micro‐structures of the corresponding xerogel networks by using the three different possible substitution patterns orthometa and para. This aromatic regioisomer‐driven strategy has been used with a cholesterol‐based gelator to prepare hollow self‐assembled organic nanotubes (S‐ONTs) with inside and outside diameters of ca. 35 and 140 nm, respectively. Electron microscopy imaging and theoretical calculations were employed to rationalize the formation mechanism of these S‐ONTs. From the three possible regioisomers, only the ortho‐disubstituted cholesteryl‐based gelator showed the optimal angle and distance between substituents to afford the formation of the cyclic assemblies required for nanotube growth by assembling 30–40 units of the gelator. This study opens fascinating opportunities to expand the synthesis of controllable and unique microstructures by modulating geometrical parameters through aromatic regioisomers.

Keywords. Gel, nanotubes, regioisomers, self-assembly, supramolecular chemistry

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