HOCA publishes a new method of addition of indoles to aliphatic β,γ-unsaturated α-ketoesters catalyzed by a chiral thiourea

Thiourea-Catalyzed Addition of Indoles to Aliphatic β,γ-Unsaturated α-Ketoesters” by Verónica Juste-Navarro, Eugenia Marqués-López and Raquel P. Herrera has been published in Asian Journal of Organic Chemistry.

DOI: 10.1002/ajoc.201500154

coverAbstract: The first thiourea-catalyzed addition reaction of indoles to aliphatic β,γ-unsaturated α-ketoesters has been developed. The easily accessible thiourea aminoindanol derivative makes this approach an interesting alternative for these aliphatic substrates, very scarcely employed in previously reported procedures, highlighting the complementarity of the strategy presented here. Final adducts, which are valuable intermediates for the obtainment of the corresponding α-amino acid or α-hydroxy acid derivatives, are obtained in good results under mild reaction conditions.

Keywords: asymmetric organocatalysis, indole, thiourea, aliphatic β,γ-unsaturated α-ketoester

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About zco1999

Club de buceo deportivo, fundado en 1999.
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